Localization of Insulinomas

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Localization of insulinomas.

HYPOTHESIS Intraoperative ultrasonography is more sensitive than preoperative and other intraoperative techniques for localizing insulinoma. DESIGN Retrospective review. SETTING A tertiary referral center. PATIENTS All patients with a biochemical diagnosis of organic hyperinsulinism who were referred to University of California, San Francisco, from 1975 to 1998. METHODS Sensitivities of...

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Glucagon-like peptide-1 receptor imaging for localization of insulinomas.

CONTEXT The surgical removal of insulinomas is hampered by difficulties to localize it using conventional radiological procedures. Recently these tumors were shown to exhibit a very high density of glucagon-like peptide-1 receptors (GLP-1R) in vitro that may be used as specific targets for in vivo receptor radiolabeling. OBJECTIVE The objective of the study was to test the 111In-labeled GLP-1...

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Neurological aspects of insulinomas.

Neurological involvement occurred in every one of a series of 30 patients with an insulinoma. The episodic nature of the hypoglycaemia caused symptoms and signs to fluctuate and often led to delay in diagnosis (mean length of history was 3 years). The commonest feature at first presentation was confusion (20 instances), but as the illness evolved, coma (16 instances) and convulsions (8 instance...

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Laparoscopic enucleation of insulinomas.

HYPOTHESIS Laparoscopic enucleation of insulinomas is safe and effective and is associated with a short hospital stay. DESIGN Case series identified through retrospective review of medical records. SETTING University of California, San Francisco Medical Center, a tertiary care referral hospital. PATIENTS Nine patients with insulinomas that were thought to be suitable for laparoscopic enuc...

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Anatomical localization of insulinomas: still a need to combine a set of diagnostic procedures.

The diagnosis of insulinoma is based on universally defined clinical and laboratory parameters (Whipple triad and fasting test). Pre-operative tumor localization is the main challenge in the diagnostic management of insulinomas. The pre-operative and/or intra-operative localization of the tumor is required for the optimal surgical approach. We describe two cases of insulinoma characterized by a...

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ژورنال

عنوان ژورنال: Archives of Surgery

سال: 1999

ISSN: 0004-0010

DOI: 10.1001/archsurg.134.8.818